An efficient combination immunotherapy for liver cancer by remodeling innate and adaptive immunity

Objective:In dissecting molecular signaling events in HCC development using mouse models,we and others identified anti-oncogenic effects for a number of pro-oncogenic molecules.To interrogate the underlying mechanisms,several groups have taken a genetic approach to delete a target gene in hepatocytes by Albumin-cre,or in hepatocytes and nonparenchymal cells(NPCs)by Mx1-cre.Interestingly.