从原发性肝癌的家族性分布探讨乙型肝炎与其发病关系

The relationship between HB and liver carcinoma: A study of familial assembly occurrence of primary liver carcinoma

近年来许多研究表明,乙型病毒性肝炎与原发性肝癌关系极为密切,二者呈家族性分布已早有报道。为进一步探讨二者关系,现将我科遇到的吉林省双阳河公社同一家族中弟兄4人同患原发性肝癌的病例,以及对其家庭及密切接触者所做的调查情况报告如下。

A familial assembly occurrence of primary liver carcinoma is reported in this paper.A patient and his three brothers died of liver carcinoma in seven and a half years.Of the 46 persons who had had close contacts with the patient and his siblings,21 had hepatomegaly,among whom 7 had anamnestic hepatits;HBsAg was positive in 10 persons(21.7%),anti-HBc was positive in 13(38.5%),HBeAg was positive in 4(8.7%);and abnormality of liver function was found in 5 persons.Evidence presented suggests apparent relationship between HB and liver carcinoma,the principal factor of HB in the occurrence of liver carcinoma,and the assembly occurrence of liver carcinoma in a family.Our results are clear enough to warrant the necessity of controlling HB in the prevention of liver carcinoma.