前列腺素E1对心力衰竭的疗效观察

Surveyingathe Actions of PGE1 on Congestive Cardiac Failure

本世纪三十年代首先由美国医生Kurzrok和Lieb发现:人的新鲜精液涂于取自病妇的子宫肌条上引起子宫肌条强烈收缩和松弛双重反应。1935年前后,Goldblatt和Von Enler各自从人精液和羊精囊的脂类提取物中得到一种活性物质,可使平滑肌收缩;注入动物可引起血压下降,Enler认为这种物质是一种不饱和脂肪酸,并定名为前列腺素(PG)。

PGE1 possesses the actions of vascular dilatation,reduction of peripheral circulatory resistance and pulmonary vascular resistance,increase of cardiac output,and dilatation of renal arteries for uresis and increase of excretion of sodium.We applied PGE1 to the treatment of 10 cases of acute and chronic cardiac failure,employing the physiological recorder(Siemens)to record heart function as one of the observation standards.The patients were given intravenous infusion of 600μg of PGE1 in 250 ml of 10%glucose.The rate of infusion was about 20 to 40 gtt per minute regulated according to the alteration of the blood pressure during infusion.The result of the treatment was remarkably good.All the symptoms and signs of the 10 cases improved markedly,such as dyspnea,engorgement of the neck veins,tachycardia,oliguria,lung rales,hepatomegaly and hypertension.The results confirmed the definite effects of PGE1 on various types of cardiac failure,especially on hypertensive cardiac failure,with the minimal side effects.