乙胺碘呋酮治疗心律失常临床观察

CLINICAL USE OF AMIODARONE IN ARRHYTHMIAS

本文报导了用乙胺碘呋酮治疗21例顽固性心律失常的临床观察。本组中的心律失常为频发房性或室性期前收缩、阵发室上性心动过速、阵发心房颤动、持续心房颤动或扑动及频发短阵室性心动过速。在1~2周,口服乙胺碘呋酮0.2一天三次。获效后用0.2一天二次。第三个月开始每服五天停二天。观察期间这些病人都不併用其它抗心律失砇?乙胺碘呋酮的疗效评定,显效7例(33%),明显好转5例(24%),有效4例(19%)及无效5例(24%)。全组的总有效率是76%。除病窦综合征外,服用乙胺碘呋酮是很安全的,没有见到任何的严重反应。如用于病窦综合症患者,应先按装按需起搏器。

This paper presents a clinical study on the use of amiodarone administered orally in treating 21 patients with various cardiac arrhythmias resistant to conventional antiarrhythmic agents.The arrhythmias included atrial or ventricular premature systoles,paroxysmal supraventricular tachycardia,paroxysmal atrial fibrillation,sustained atrial fibrillation or flutter and paroxysmal transient ventricular tachycardia.Amiodarone was administered orally in doses of 200 mg three times daily during the initial 1~2 weeks.After the clinical effect was observed,a maintenance dose of 200 mg two times daily was given.From the begining of the third month the drug was withdrawn for two days every week.During the period of study no other antiarrhythmic agents were given to the patients.In this series,the antiarrhythmic effect of amiodarone proved to be excellent in 7 cases(33%),very good in 5 cases(24%),fairly good in 4 cases(19%)and poor or none in 5 cases(24%).The total effective rate of the entire series was 76%.Amiodarone appears to be effective for both atrial and ventricular arrhythmias,and may be given with safety except in cases of the sick sinus syndrome,in which the use of an artificial pacemaker is advisable before the drug is administered.