阿尔茨海默病外周血生物标志物研究进展

Research progress of peripheral blood biomarkers of Alzheimer’s disease

阿尔茨海默病(Alzheimer’s disease,AD)是一种表现为认知功能障碍进行性加重的神经退行性疾病,随着中国快速老龄化,AD的疾病负担越发沉重。为了尽早对疾病进行干预,研究者们致力于寻找有效且便于检测的早期AD生物标志物。其中外周血标志物由于其采集方便、创伤小的特点,成为一种有潜力在社区人群中普及的早期筛查和随诊手段。本文就AD的外周血生物标志物研究进展进行综述。

Alzheimer’s disease(AD)is a neurodegenerative disease characterized by progressive cognitive impairment.With the rapid aging of China,the disease burden is becoming heavier.In order to early prevent and treat the disease,researchers committed to find effective and easily detectable biomarkers for early recognition of AD.Among them,the peripheral blood biomarkers detection is a potential method for early screening and follow-up in the community population because of its convenient collection and little trauma.In this paper,the research progress of peripheral blood biomarkers of AD was reviewed.