ACE基因I/D多态性与云南纳西族人群高原低氧习服、高血压及血脂异常的相关性研究

Correlation between ACE Gene I/D Polymorphism and High-Altitude Hypoxia Acclimatization,Hypertension and Dyslipidemia in Naxi Ethnic Group of Yunnan Province

目的:分析ACE基因I/D多态性在不同海拔纳西族人群中的分布,探索ACE基因I/D多态性与云南丽江纳西族人群高原低氧习服、高血压及血脂异常的关系。方法:采用分层随机抽样的方法从云南省丽江市高海拔地区和中海拔地区共抽取265例父母均为纳西族、彼此间无血缘关系、三代内无族外通婚的世居四代以上的纳西族人群作为研究对象,检测研究对象的ACE基因I/D片段,统计分析其ACE基因I/D多态性与海拔、高血压及血脂异常的关系。结果:高海拔纳西族人群中ACE基因I等位基因频率和含I等位基因的基因型(II+ID)频率明显高于中海拔纳西族人群(P<0.05)。纳西族高血压组ACE基因I等位基因频率和含I等位基因的基因型(II+ID)频率明显高于非高血压组(P<0.01)。血脂异常组ACE基因I等位基因频率高于血脂正常组(P<0.05)。ACE基因三种基因型(II、ID、DD)的甘油三酯水平差异有统计学意义(P<0.05),II基因型甘油三酯水平明显高于DD基因型(P<0.05)。结论:ACE基因I/D多态性与纳西族人群高原低氧习服、高血压及血脂异常具有相关性,II、ID基因型和I等位基因有利于高海拔纳西族人群的高原低氧习服,II、ID基因型和I等位基因可能增加纳西族人群发生高血压的风险,而I等位基因是纳西族人群血脂异常的危险因素,II基因型与较高水平的甘油三酯有关。

Objective:This study is aimed to analyze the distribution of ACE gene I/D polymorphism in different altitudes of Naxi minority,and explore its relationship with high altitude acclimatization,hypertension and dyslipidemia in the Naxi minority of Lijiang,Yunnan,China.Methods:Eight Naxi villages from highaltitude and mid-altitude areas in Lijiang,Yunnan were randomly selected by using stratified random sampling.A total of 265 unrelated,three-generation resident Naxi individuals with no outside ethnic marriage were selected and their ACE gene I/D was genotyped.The associations between ACE gene I/D polymorphism and altitude,hypertension and dyslipidemia in Naxi minority were analyzed by using statistical methods.Results:The frequency of ACE gene I allele and II/ID genotype containing I allele in high-altitude Naxi minority was significantly higher than that in mid-altitude(P<0.05).The frequency of ACE gene I allele and II/ID genotype containing I allele were higher in the hypertension group than that in the non-hypertension group(P<0.01).The frequency of ACE gene I allele was higher in the dyslipidemia group than that in the normal group(P<0.05).There was a statistical difference in triglyceride levels among the three genotypes(P<0.05),and the overall mean of triglyceride level in II genotype was significantly higher than that in DD genotype(P<0.05).Conclusion:ACE gene I/D polymorphism is related to high altitude acclimatization,hypertension and dyslipidemia in Naxi minority.II/ID genotypes and I allele are beneficial for high altitude acclimatization in high-altitude Naxi minority,which might increase the risk of hypertension in Naxi minority.The I allele is a risk factor for dyslipidemia in Naxi minority,and the II genotype is associated with higher triglyceride level.