氟西汀治疗脑梗死后抑郁患者的疗效

Therapeutic effect of fluoxetine on depression patients after cerebral infarction

目的探讨脑梗死后并发抑郁症的患者应用氟西汀的治疗效果。方法选择2017年1月~2019年1月期间我院收治的100例脑梗死后并发抑郁症的患者为研究对象,采用随机数字表法分组,对照组(n=50)给予常规方案治疗。观察组(n=50)在此基础上加用氟西汀治疗。比较两组患者的总有效率,抑郁评分,神经功能缺损、认知功能、生活质量评分,不良反应率。结果观察组总有效率(94.00%)明显高于对照组(72.00%)(P<0.05);两组治疗前,抑郁评分无统计学差异(P>0.05),干预后两组患者评分较前均有降低,且观察组较对照组降低程度更为显著(P<0.05);两组治疗前,神经功能缺损、认知功能、生活质量评分无统计学差异(P>0.05);治疗后,神经功能缺损评分较前均有降低,认知功能和生活质量评分较前均有升高,且对照组变化程度更为显著(P<0.05)。观察组和对照组不良反应无明显差异(P>0.05)。结论常规治疗基础上加用氟西汀可以明显改善脑梗死后并发抑郁患者的负性情绪,促进神经功能、认知功能的恢复,提高生活质量,且安全性较好。

Objective To investigate the effect of fluoxetine in patients with depression after cerebral infarction.Methods One hundred patients with depression after cerebral infarction admitted to our hospital from January 2017 to January 2019 were enrolled and randomly divided into two groups.The control group(n=50)were treated with conventional regimens,while the observation group(n=50)plus fluoxetine intervention.The total effective rate,depression score,neurological deficit,cognitive function,quality of life score,adverse reactions between two group were compared.Results The total effective rate in the observation group(94.00%)was higher than that(94.00%)in the control group(P<0.05).There was no difference in the depression score,neurological deficit,cognitive function and quality of life before treatment(P>0.05).After treatment,all the scores of scales mentioned above were improved both in two groups,however,the improvement in the observation group was more significant than that in the control group(P<0.05).Before treatment,there was no difference in the quality of life scores(P>0.05).There was no significant difference in the adverse reaction rate between the groups(P>0.05).Conclusion Fluoxetine can improve the level of depression,promote neurological and cognitive functions,and enhance quality of life in depression patients after cerebral infarction.The security is good.