艾司西酞普兰和氟西汀对抑郁症的疗效和认知改善情况对比

Clinical efficacy and cognitive improvement of escitalopram and fluoxetine in the treatment of depression

目的对比艾司西酞普兰和氟西汀对抑郁症的疗效和对认知改善的作用。方法将2017年1月~2019年1月我院收治的抑郁症患者60例随机分为2组,每组30例。对照组采用氟西汀治疗,观察组采用艾司西酞普兰治疗。比较两组治疗前后HAMD、MoCA评分情况、临床疗效、生活质量以及不良反应。结果治疗前观察组和对照组HAMD、MoCA评分上无明显差异(P=0.457/0.624),治疗后观察组优于对照组(P=0.000);对照组有效率为86.67%,优于观察组的63.33%(P=0.000);观察组在情感职能、生理、躯体、社会等功能评分上优于对照组(P=0.000);观察组不良反应发生率为6.67%,低于对照组的23.33%(P=0.000)。结论与氟西汀相比,艾司西酞普兰可快速改善抑郁症患者的抑郁症状和认知功能,提升患者生活质量,且不良反应较少。

Objective To investigate the efficacy and changes of cognitive function of escitalopram and fluoxetine in depression patients.Methods From January 2017 to January 2019,60 depression patients were enrolled and randomly divided into 2 groups,30 patients in each group.The control group was treated with fluoxetine,while the observation group was treated with escitalopram.The HAMD and MoCA scores,clinical efficacy,quality of life,and adverse reactions were compared between two groups before and after treatment.Results There were no difference between two group on scores of HAMD and MoCA before treatment,after treatment,the scores of HAMD and MoCA in observation group was better than those in the control group(P=0.000).The efficiency of the observation group was 86.67%,which was better than the control group(63.33%).In the emotional function,physiology,physical,social and other functional scores in the observation group was better than those in the control group(P=0.000).The incidence of adverse reactions in observation group was 6.67%,which was lower than that in the control group(23.33%).Conclusion The escitalopram can rapidly improve depressive symptoms,cognitive function and the quality of life of depression patients with fewer adverse reactions.