复方苦参注射液辅助治疗非小细胞肺癌的研究进展

Research progress of compound Kushen injection in the adjuvant treatment of non-small cell lung cancer

非小细胞肺癌(nonsmall-cell lung cancer,NSCLC)起病隐匿,部分患者确诊时已属晚期,多采用以铂类为基础的两药联用姑息性化疗方案,但化疗方案用药安全性低,患者多因不耐受其不良反应而停/换药。复方苦参注射液有清热利湿、凉血解毒以及散结止痛之功,其在临床被广泛用于NSCLC的辅助治疗,助放化疗抗肿瘤之效,调节肿瘤标志物水平,延长患者生存期,同时减轻其不良反应,缓解患者癌性疼痛,提高患者免疫力及生活质量。现对复方苦参注射液辅助治疗NSCLC的研究进展作综述,以期为NSCLC的临床治疗及研究提供一定的思路和依据。

Non-small cell lung cancer(NSCLC)has an insidious onset,and some of the diagnosed cases are already in advanced stage,and most of them adopt platinum-based two-drug palliative chemotherapy regimen,but the safety of chemotherapy regimen is low,and patients often stop/change the drug due to intolerance to the adverse effects.Compound Kushen injection has the function of clearing heat and dampness,cooling blood and detoxifying,expelling nodules to relieve pain.It is widely used in clinical adjuvant treatment of NSCLC,which can help radiotherapy and chemotherapy to combat tumor,regulate tumor markers levels and prolong patients'survival period,as well as alleviate adverse effects,relieve cancer pain,improve patients'immunity and quality of life.This article reviewed the research progress of compound Kushen injection in the adjuvant treatment of NSCLC,to provide some ideas and basis for its application and research in the treatment of NSCLC.