医用臭氧水穴位注射联合骶髂关节注射治疗强直性脊柱炎临床观察

Clinical Observationon Medical Ozonated Water Acupoint Injection Combined with Sacroiliac Joint Injection in the Treatment of Ankylosing Spondylitis

目的评价医用臭氧水穴位注射联合骶髂关节注射治疗强直性脊柱炎48周的临床疗效和安全性。方法将纳入的72例强直性脊柱炎患者,随机分为臭氧水组和药物对照组,每组36例。臭氧水组:医用臭氧水穴位注射治疗;药物对照组:口服柳氮磺胺吡啶肠溶片、塞来昔布胶囊治疗。于治疗前和治疗后第12周、24周、48周,采用BASDAI、BASFI、BASMI与CRP进行疗效评价,并于治疗后进行安全性评价。结果臭氧水组和药物对照组治疗第12、24、48周BASDAI、BASFI、BASMI评分及CRP水平均较治疗前明显下降,差异有统计学意义(P<0.05);组间比较,臭氧水组治疗第12、24、48周BASDAI、BASFI、BASMI评分及CRP水平与药物对照组相比,差异均无统计学意义(P>0.05)。药物对照组34例患者,有4例出现轻度不良反应,6例出现中度不良反应。臭氧水组34例患者,未见不良反应。2组安全性相比,差异有统计学意义(P<0.05)。结论医用臭氧水穴位注射联合骶髂关节注射治疗AS可明显缓解患者临床症状,改善功能活动和脊柱活动度,降低炎症反应,综合有疗性及安全性,优于药物对照组。

Objective To evaluate the efficacy and safety of medical ozonated water acupoint injection combined with sacroiliac joint injection on the treatment of ankylosing spondylitis for 48 weeks.Methods 72 AS patients were randomly divided into ozonated water group of 36 cases and control group of 36 cases.20μg/ml ozonated water was injected into Dazhui(GV14),Fengchi(GB20),Shenshu(BL23),Dachangshu(BL25),Ashi acupoint,part of Jiaji acupoints(EX-B2)and sacroiliac joint.2-5 ml/acupoint,10 ml/site,once a week for treatment,12 weeks for 1 course.After treatment for 12 weeks,treatment time interval was extended,then every 12 weeks respectively every 10 days,15 days and 30 days of once treatment,a total of 48 weeks.The control group took oral sulfasalazine enteric-coated tablets,the first week,0.25 g,bid;the second week,0.5 g bid;the third week,0.75 g,bid;for the remaining 45 weeks,1 g,bid.Celecoxib capsules:0.2 g,bid,for 48 weeks.Evaluation time point and method was BASDAI,BASFI,BASMI,CRP were evaluated before treatment and after treatment for 12,24,48 weeks.Safety was evaluated after treatment.Results After treatment for 12,24,48 weeks,BASDAI,BASFI,BASMI score and CRP were significantly lower than before treatment in two groups.It had statistically significant difference(P<0.05).BASDAI,BASFI,BASMI score and CRP of treatment for 12,24,48 weeks,were no statistically significant difference in two groups(p>0.05).Conclusion Medical ozonated water acupoint injection combined with sacroiliac joint injection on the treatment of AS can dramatically relief clinical symptoms,function activity,spinal mobility and reduce inflammation.For efficacy and safety,ozonated water treatment for AS is better than the control group.