摘要
G蛋白偶联受体激酶2(GRK2)为G蛋白偶联受体激酶家族重要成员,GRK2结构的N端和C端共同发挥受体识别和亚细胞定位的功能。GRK2可磷酸化G蛋白偶联受体(GPCRs)和非GPCRs途径参与的相关信号通路,调节机体病理生理过程。GRK2在心脏、肝、肾、肺等多种器官纤维化中表达异常,本文就GRK2在纤维化疾病中的调控作用进行综述。
Objective G protein coupled receptor kinase 2(GRK2)is an important member of the G protein coupled receptor kinases(GRKs)family.The N-terminus and C-terminus of GRK2 structure play a role in receptor recognition and subcellular localization.GRK2 can regulate the pathophysiological processes of the body through phosphorylation of G protein-coupled receptors(GPCRs)and non-GPCRs pathways.Studies have shown that the expression of GRK2 in cardiac fibrosis,liver fibrosis,kidney fibrosis and pulmonary fibrosis is abnormal.This article reviews the role of GRK2 in fibrotic diseases.
作者
李秀芹
孙妩弋
李南
杜佳佳
魏伟
LI Xiu-qin;SUN Wu-yi;LI Nan;DU Jia-jia;WEI Wei(Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-Inflammatory and Immune Medicine,Ministry of Education,Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine,Hefei 230032,Anhui Province,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2020年第4期466-470,共5页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金资助项目(81770605,81300332)
安徽省高校优秀青年人才支持计划项目重点课题资助项目(gxyqZD2018024).
关键词
G蛋白偶联受体
G蛋白偶联受体激酶2
纤维化
细胞外基质
G protein-coupled receptors
G protein coupled receptor kinase 2
fibrosis
extracellular matrix