G蛋白偶联受体激酶2对纤维化疾病调控作用的研究现状

Advances in the role of G protein-coupled receptor kinase 2 in fibrotic diseases

G蛋白偶联受体激酶2(GRK2)为G蛋白偶联受体激酶家族重要成员,GRK2结构的N端和C端共同发挥受体识别和亚细胞定位的功能。GRK2可磷酸化G蛋白偶联受体(GPCRs)和非GPCRs途径参与的相关信号通路,调节机体病理生理过程。GRK2在心脏、肝、肾、肺等多种器官纤维化中表达异常,本文就GRK2在纤维化疾病中的调控作用进行综述。

Objective G protein coupled receptor kinase 2(GRK2)is an important member of the G protein coupled receptor kinases(GRKs)family.The N-terminus and C-terminus of GRK2 structure play a role in receptor recognition and subcellular localization.GRK2 can regulate the pathophysiological processes of the body through phosphorylation of G protein-coupled receptors(GPCRs)and non-GPCRs pathways.Studies have shown that the expression of GRK2 in cardiac fibrosis,liver fibrosis,kidney fibrosis and pulmonary fibrosis is abnormal.This article reviews the role of GRK2 in fibrotic diseases.