大剂量氨溴索静脉滴注对老年非小细胞肺癌(NSCLC)肺叶切除术后患者的疗效观察

Efficacy of high-dose intravenous infusion of ambroxol in elderly patients with NSCLC after lobectomy

目的:探讨大剂量氨溴索静脉滴注对老年非小细胞肺癌(NSCLC)肺叶切除术后肺功能、心肌酶谱及氧化应激的影响。方法:随机将125例择期行胸腔镜肺叶切除术的NSCLC老年患者分为两组,对照组给予中等剂量氨溴索静脉滴注治疗,观察组给予大剂量氨溴索静脉滴注治疗,观察、分析两组治疗效果。结果:治疗后,观察组LDH、AST、CK、CK-MB、SOD、PEF25、PEF50、TLC、FEV1水平高于对照组,MDA水平低于对照组。两组不良反应比较,差异没有统计学意义(P>0.05)。结论:大剂量氨溴索治疗老年NSCLC肺叶切除术后患者,有利于患者心、肺功能恢复。

Objective:To investigate the efficacy of high-dose intravenous infusion of ambroxol on pulmonary function,myocardial enzyme spectrum and oxidation index levels in elderly patients with NSCLC after lobectomy.Methods:125 elderly patients with non-small cell lung cancer(NSCLC)scheduled to undergo thoracoscopic lobectomy were randomized into 2 groups.The control group were treated with medium-dose intravenous infusion of ambroxol,while the observation group were given high-dose intravenous infusion of ambroxol.The clinical efficacy of the two groups was compared.Results:After treatment,the levels of LDH,AST,CK,CK-MB,SOD,PEF25,PEF50,TLC and FEV1 in the observation group were higher than those in the control group,and MDA level in the observation group was lower than that of the control group.There was no statistical significance of adverse reactions in patients between the two groups(P>0.05).Conclusion:High-dose ambroxol is beneficial to the recovery of cardiopulmonary function in patients with NSCLC after lobectomy.