药物治疗与外科手术治疗分泌性中耳炎的效果及安全性

Efficacy and safety of drug therapy and surgical treatment for secretory otitis media/WANG Xiaoyu

目的:探讨药物治疗与外科手术治疗分泌性中耳炎(SOM)的疗效及安全性。方法:82例SOM患者,随机分为A组和B组。A组40例,采用药物治疗(经鼓室注入曲安奈德及氨溴索);B组42例,采用手术治疗(鼓膜切开后置管)。比较两组临床疗效、听力阈值及不良反应。结果:A组治疗总有效率97.50%,高于B组80.95%,差异有统计学意义(P<0.05);治疗后,两组听力阈值均低于治疗前,且A组低于B组(P<0.05);不良反应发生率7.50%,低于B组23.81%(P<0.05)。结论:与外科手术治疗相比,经鼓室注入曲安奈德及氨溴索治疗SOM,不良反应低,疗效好。

Objective:To compare the efficacy and safety of drug therapy and surgical treatment for secretory otitis media(SOM).Methods:82 SOM patients were randomized into group A and B.40 patients in group A received drug treatment(triamcinolone acetonide and ambroxol injection through the tympanum),while 42 patients in group B underwent surgical treatment(catheterized after the tympanic membrane was incised).The clinical efficacy,hearing threshold and adverse reactions of patients were compared between the two groups.Results:The total effective rate in group A was 97.5%,higher than that in group B,which was of statistical significance(P<0.05);after treatment,the hearing thresholds of both groups were lower than those before treatment,and group A’shearing threshold was lower than Group B’s(P<0.05);and the incidence of adverse reactions in group A was 7.50%,lower than 23.81%in group B(P<0.05).Conclusion:Compared with surgical treatment,triamcinolone acetonide and ambroxol injection through the tympanum has a better curative effect in the treatment of SOM with lower adverse reaction and high safety.