银杏叶提取物注射液联合丁苯酞注射液治疗急性脑梗死的效果

Effect of Ginkgo biloba extract injection combined with butylphthalide injection in the treatment of acute cerebral infarction

目的:探讨银杏叶提取物联合丁苯酞对急性脑梗死患者的影响。方法:选取2018年8月至2019年7月我院收治的106例急性脑梗死患者,按随机数字表法分为研究组(53例)与对照组(53例)。对照组加用丁苯酞治疗,研究组在此基础上加用银杏叶提取物治疗。比较2组临床效果及不良反应。结果:研究组治疗总体有效率显著高于对照组(P<0.05)。治疗后研究组全血高切黏度、血浆黏度、纤维蛋白原、血清羟基自由基(OH)、过氧化脂质(PLO)及一氧化氮(NO)等改善程度均显著高于对照组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论:银杏叶提取物注射液联合丁苯酞注射液治疗急性脑梗死疗效较佳,能有效改善患者血液流变学及抑制氧自由基生成。

Objective:To investigate the effect of Ginkgo biloba extract combined with butylphthalide on patients with acute cerebral infarction.Methods:106 patients with acute cerebral infarction in our hospital from August 2018 to July 2019 were selected and randomly divided into study group(53 cases)and control group(53 cases).The control group was treated with butylphthalide,and the study group was treated with Ginkgo biloba extract.The clinical effects and adverse reactions were compared between the two groups.Results:The total effective rate of the study group was significantly higher than that of the control group(P<0.05).After treatment,the improvement of whole blood high shear viscosity,plasma viscosity,fibrinogen,serum hydroxyl radical(OH),lipid peroxide(PLO)and nitric oxide(no)in the study group were significantly higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Ginkgo biloba extract injection combined with butylphthalide injection is effective in the treatment of acute cerebral infarction,which can effectively improve hemorheology and inhibit the generation of oxygen free radicals.