青蒿琥酯治疗肺孢子菌肺炎的实验研究

Experimental study on artesunate in the treatment of Pneumocystis pneumonia

目的:探讨青蒿琥酯对大鼠卡氏肺孢子菌肺炎的治疗作用。方法:以地塞米松诱发建立肺孢子菌肺炎(Pneumocystis pneumonia,PCP)动物模型。PCP模型组给予生理盐水,治疗组给予60 mg·kg-1·d-1青蒿琥酯干预。检测肺印片中的肺孢子菌包囊数,分析肺组织的病理学变化。结果:模型组大鼠肺组织中可见大量肺孢子菌的包囊或滋养体,病理学观察显示模型组肺实变明显,炎性细胞及炎性渗出物聚集于肺泡腔及肺泡间质内;青蒿琥酯干预组肺印片包囊数明显减少,卡氏肺孢子菌所引起的肺部结构损伤减轻,肺炎性损伤明显改善。结论:青蒿琥酯对卡氏肺孢子菌肺炎大鼠有良好治疗效果。

Objective:To investigate the therapeutic effect of artesunate on Pneumocystis carinii pneumonia in rats.Methods:The animal model of Pneumocystis pneumonia(PCP)was established by dexamethasone.PCP model group was given normal saline,and the treatment group was given artesunate 60 mg·kg-1·d-1.The number of Pneumocystis cysts in lung print was detected and the pathological changes of lung tissue were analyzed.Results:A large number of Pneumocystis cysts or trophozoites were found in the lung tissue of the model group,and the pathological observation showed that the lung consolidation was obvious in the model group,and the inflammatory cells and exudates accumulated in the alveolar cavity and alveolar interstitium;the number of lung imprint cysts in the artesunate intervention group was significantly reduced,the lung structure damage caused by Pneumocystis carinii was reduced,and the pneumonia injury was significantly improved.Conclusion:Artesunate has good therapeutic effect on Pneumocystis carinii pneumonia in rats.