小剂量尿激酶联合氯吡格雷、阿司匹林对进展性脑梗死患者神经功能缺损评分及生活质量的影响

Effects of low-dose urokinase combined with clopidogrel and aspirin on neurological deficit score and quality of life in patients with progressive cerebral infarction

目的:观察小剂量尿激酶联合氯吡格雷、阿司匹林对进展性脑梗死患者神经功能缺损评分(NIHSS)及生活质量的影响。方法:选取我院86例进展性脑梗死患者,按照治疗方法分组,每组43例。对照组予以氯吡格雷、阿司匹林治疗,观察组在对照组基础上予以小剂量尿激酶治疗。对比两组临床疗效、治疗前后NIHSS评分、Barthel指数(BI)、凝血酶原时间(PT)、血浆黏度(PV)、纤维蛋白原(Fib)。结果:观察组治疗总有效率88.37%(38/43)高于对照组69.77%(30/43)(P<0.05);治疗2周后两组NIHSS评分均降低,BI评分均升高,观察组NIHSS评分低于对照组,BI评分高于对照组(P<0.05);治疗2周后两组PV、Fib均降低,观察组PV、Fib低于对照组(P<0.05)。结论:小剂量尿激酶联合氯吡格雷、阿司匹林治疗进展性脑梗死患者,可提高治疗效果,改善血液流变学,减轻神经功能缺损,提高患者生活质量。

Objective:To observe the effects of low-dose urokinase combined with clopidogrel and aspirin on neurological deficit score(NIHSS)and quality of life in patients with progressive cerebral infarction.Methods:86 patients with progressive cerebral infarction in our hospital were selected and grouped according to treatment methods,each with 43 cases.The control group were treated with clopidogrel and aspirin,while the observation group were treated with low-dose urokinase on the basis of the control group.The clinical efficacy,NIHSS score before and after treatment,Barthel index(BI),prothrombin time(PT),plasma viscosity(PV)and fibrinogen(Fib)were compared between the two groups.Results:The total effective rate in the observation group was 88.37%(38/43),higher than 69.77%(30/43)in the control group(P<0.05).After 2 weeks of treatment,the NIHSS scores of both groups decreased,and the BI scores increased.The NIHSS score was lower than that of the control group,while BI score was higher than that of the control group(P<0.05);PV and Fib of the two groups were reduced,while PV and Fib of the observation group were lower than those of the control group(P<0.05).Conclusion:Low-dose urokinase combined with clopidogrel and aspirin can improve the treatment effect in patients with progressive cerebral infarction,improve hemorheology,reduce neurological deficits and improve the quality of life of patients.