益生菌和锌剂联合治疗儿童腹泻的效果分析

Effect analysis of zinc combined with probiotics in treatment of diarrhea children

目的:探讨益生菌和锌剂联合治疗儿童腹泻的效果。方法:选取96例腹泻患儿为研究对象,随机分为单纯补锌组和联合治疗组,每组各48例。在给予饮食调整、抗感染、电解质调节和补液等常规治疗的基础上,单纯补锌组患儿加用葡萄糖酸锌口服液,联合治疗组在单纯补锌组的基础上,加用枯草杆菌肠球菌二联活菌颗粒。观察记录两组患儿的住院时间、大便次数恢复时间、大便性状恢复时间和体温恢复时间,对两组患儿临床治疗效果进行比较。结果:联合治疗组患儿住院时间、大便次数恢复时间、大便性状恢复时间和体温恢复时间与单纯补锌组比较明显缩短,差异有统计学意义(P<0.05)。联合治疗组患儿完全缓解率和缓解率均高于单纯补锌组(P<0.05),联合治疗组患儿治疗后1个月,2个月,3个月腹泻复发率均低于单纯补锌组,差异有统计学意义(P<0.05)。结论:益生菌和锌剂联合治疗儿童腹泻,可以缩短患儿病程,治疗效果较好,降低复发率。

Objective:To explore the effect of probiotic and zinc in treatment of children diarrhea.Methods:96 children with diarrhea were selected as the study subjects.They were randomly divided into the zinc supplement group and the combined treatment group,with 48 cases in each group.On the basis of routine treatment such as dietary adjustment,anti-infection,electrolyte regulation and rehydration,the children in the zinc supplement group were given oral solution of zinc gluconate,and the children in the combined treatment group were given live bacteria granules of bacillus subtilis enterococcus on the basis of the zinc supplement group.The hospital stay,stool frequency recovery time,stool character recovery time and body temperature recovery time of the two groups of children were observed and recorded.The clinical treatment effect of the two groups of children was compared.Results:Compared with the zinc supplement group,the duration of hospital stay,stool frequency recovery time,stool characteristics recovery time and body temperature recovery time in the combined treatment group were significantly shortened(P<0.05).The complete response rate and response rate in the combined treatment group were significantly higher than that in the zinc supplement group(P<0.05),and the recurrence rate of diarrhea in the combined treatment group was lower than that in the zinc supplement group on one,two and three monthes after treatment(P<0.05).Conclusion:Zinc combined with probiotics in the treatment of diarrhea children can shorten the course of disease,has a good therapeutic effet and reduce the incidence of recurrent disease.