法舒地尔对肺心病患者肺功能指标、炎症因子及血管生长因子的影响

Effects of fasudil on pulmonary function, inflammatory factors and vascular growth factors in patients with cor pulmonale

目的:探讨法舒地尔治疗对肺心病患者肺功能指标、炎症因子及血管生长因子的影响。方法:92例肺源性心脏病患者,随机分为2组,每组各46例。对照组采用常规对症治疗,观察组在对照组的基础上加法舒地尔治疗。比较两组患者临床疗效、肺功能指标、炎症因子、血管生长因子等。结果:观察组总有效93.48%,高于对照组78.28%,差异有统计学意义(P<0.05)。治疗后两组患者肺动脉收缩压、IL-6、TNF-α、hs-CRP及VEGF水平均明显下降,PaO2及PaCO2均明显上升,观察组优于对照组,差异有统计学意义(P<0.05)。观察组与对照组的不良反应发生率无统计学差异(P>0.05)。结论:法舒地尔能明显增强治疗肺心病的临床疗效。

Objective: To investigate the effect of fasudil on pulmonary function, inflammatory factors and vascular growth factors in patients with cor pulmonale. Methods: 92 patients with pulmonary heart disease were randomly divided into 2 groups, 46 in each group. The control group was treated with conventional symptomatic treatment, and the observation group was treated with fasudil on the basis of the control group. The clinical effect, lung function index, inflammatory factor and vascular growth factor were compared between the two groups. Results: The total effective rate of the observation group was 93.48%, which was higher than 78.28% of the control group, the difference is statistically significant(P<0.05). After treatment, the levels of pulmonary artery systolic pressure, IL-6, TNF-α, hs CRP and VEGF in the two groups were significantly decreased, PaO2 and PaCO2 were significantly increased, and the difference between the two groups was statistically significant(P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05). Conclusion: Fasudil can obviously enhance the clinical effect of treating cor pulmonale.