脐带血在诊断新生儿ABO溶血病(ABO-HDN)中的应用价值

Value of cord blood in the diagnosis of neonatal ABO hemolytic disease(ABO-HDN)

目的:探讨脐带血溶血3项指标以及血清总胆红素对于早期诊断新生儿ABO溶血病(ABO-HDN)的临床价值。方法:2015年7月至2018年7月,采集80例新生儿的脐带血及静脉血,进行溶血3项检测,分析ABO-HDN检出率以及确诊率。分析新生儿脐带血血清总胆红素含量及其与新生儿高胆红素血症发生时间的关系。结果:脐带血抗体释放试验,游离抗体试验的阳性检出率以及ABO-HDN确诊率较静脉血高(P<0.05)。新生儿高胆红素血症发生时间延长,脐带血胆红素含量水平降低(P<0.05)。结论:脐带血采集方便快捷,对ABO-HDN检出率高。

Objective: To explore 3 indexes of hemolysis and serum total bilirubin for early diagnosis of neonatal ABO hemolytic disease(ABO-HDN). Methods: From July 2015 to July 2018, cord blood and venous blood of 80 newborns were collected for testing 3 indexes of hemolysis, and the detection rate and diagnosis rate of ABO-HDN were analyzed. To analyze the relationship between the content of total bilirubin in cord blood and the time of hyperbilirubinemia. Results: The positive rate of antibody release test, free antibody test and ABO-HDN diagnosis rate of cord blood were higher than that of venous blood(P<0.05). The time of hyperbilirubinemia was prolonged and the level of bilirubin in cord blood was decreased(P<0.05). Conclusion: Cord blood collection is convenient and fast, and the positive rate of ABO-HDN was higher by testing cord blood.