宫腔镜联合来曲唑治疗子宫内膜异位症的疗效及安全性

Efficacy and safety of hysteroscopy combined with letrozole in the treatment of endometriosis

目的:探讨宫腔镜联合来曲唑治疗子宫内膜异位症的疗效和安全性。方法:2017年3月至2018年4月,我院诊治的60例子宫内膜异位症患者,随机分为干预组,30例,采用宫腔镜联合来曲唑治疗;常规组,30例,采用宫腔镜治疗。比较两组患者的疗效、激素变化情况和不良反应发生率。结果:干预组治疗总有效率96.67%,高于常规组76.67%,差异有统计学意义(P<0.05)。治疗前、后,干预组和常规组FSH、LH比较,差异无统计学意义(P>0.05)。治疗后,干预组E2的水平低于常规组(P<0.05)。干预组并发症的发生率与常规组比较,差异无统计学意义(P>0.05)。结论:宫腔镜联合来曲唑治疗子宫内膜异位症能提高疗效,安全性好。

Objective: To investigate the efficacy and safety of hysteroscopy combined with letrozole in the treatment of endometriosis. Methods: From March 2017 to April 2018, 60 patients with endometriosis in our hospital were randomly divided into intervention group(30 cases), which were treated by hysteroscopy combined with letrozole, and routine group(30 cases) were treated by hysteroscopy. The therapeutic effect, hormone changes and adverse reactions were compared between the two groups. Results: The total effective rate of intervention group was 96.67%, which was higher than 76.67% of routine group(P<0.05). There was no significant difference in FSH and LH between intervention group and routine group before and after treatment(P>0.05). After treatment, the level of E2 in the intervention group was lower than that in the routine group(P<0.05). There was no significant difference in the incidence of complications between the intervention group and the routine group(P>0.05). Conclusion: Hysteroscopy combined with letrozolidine can improve the therapeutic effect and safety of endometriosis.