肺癌患者常见凝血指标的变化和临床意义

Changes and Clinical Significance of Common Coagulation Indicators in Patients with Lung Cancer

目的:观察肺癌患者常见凝血指标纤维蛋白原(fibrinogen,FIB)、血小板(plateletcount,PLT)、活化部分凝血活酶时间(activatedpartial thromboplastin time,APTT)、凝血酶原时间(prothrombin time,PT)、凝血活酶时间(thromboplastin time,TT)与健康人群的差异并分析其与临床病理特征之间的关系。方法:采用回顾性研究方法收集2018年11月1日至2019年11月1日在佳木斯大学附属第一医院就诊并明确诊断的肺癌患者60例作为肺癌组,记录患者的性别,年龄,病理类型。选取同时段在我院进行体检者40例作为健康组,同时记录体检者的性别,年龄等资料。分析两组的FIB、PLT、APTT、PT、TT检验结果。结果:肺癌患者纤维蛋白原(FIB)、血小板(PLT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血活酶时间(TT)高于健康组,纤维蛋白原(FIB)、血小板(PLT)与健康组的差异具有统计学意义(p<0.05),鳞癌、腺癌、小细胞肺癌的纤维蛋白原(FIB)、血小板(PLT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)指标均没有显著差异(p>0.05)。结论:肺癌患者大多存在凝血功能异常的现象,通过上述检测指标,有助于辅助肺癌的早期诊断和预后观察。

Objective:To observe fibrinogen(FIB),platelet count(PLT),activated partial thromboplastin time(APTT),and prothrombin time(PT),Thromboplastin time(TT)and the difference between healthy people and analyze its relationship with clinicopathological characteristics.Methods:A retrospective study was conducted to collect 60 patients with lung cancer diagnosed and diagnosed at the First Affiliated Hospital of Jiamusi University from November 1,2018 to November 1,2019 as the lung cancer group.The gender,age,and pathology of the patients were recorded.Types of.Forty patients who underwent a physical examination in our hospital at the same time were selected as the health group,and the gender,age and other data of the physical examination were recorded at the same time.The FIB,PLT,APTT,PT,and TT test results of the two groups were analyzed.Results:Fibrinogen(FIB),platelets(PLT),activated partial thromboplastin time(APTT),prothrombin time(PT),and thromboplastin time(TT)were higher in lung cancer patients than in the healthy group.Fibrinogen(The difference between FIB),platelet(PLT)and healthy group was statistically significant(p<0.05).Fibrinogen(FIB),platelet(PLT),activated partial thromboplastin time of squamous cell carcinoma,adenocarcinoma,small cell lung cancer(APTT),prothrombin time(PT),and thrombin time(TT)were not significantly different(p>0.05).Conclusion:Most patients with lung cancer have abnormal blood coagulation function.The above-mentioned detection indicators are helpful to the early diagnosis and prognosis observation of lung cancer.