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Fluorescent probes for glucolipid metabolism of bacterial cell wall

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摘要 Cell wall is a basic component of bacteria that promotes bacteria to adapt the complicated environment as well as play an essential role in antimicrobial resistance.The structure of bacterial cell wall is remarkably rich,and some complex components,such as peptidoglycan,lipopolysaccharide,and peptidoglycan-arabinogalactan et al.,can only be found in bacteria.Furthermore,the biosynthesis and transfer of these glycolipids are indispensable for bacteria during cell elongation.And the process of biosynthesis and transfer are generally associated with metabolism and sophisticated enzyme mechanisms.However,how the metabolic process takes place,what role enzymes play in this process and how they function have been major concerns for scientists in this field.Numerous significant progresses on fluorescent probes and biological imaging bring opportunity for the studying of metabolism and enzyme mechanisms recently due to its non-invasive and high sensitivity.In this review,we focused on metabolic fluorescent probes for the detection of glycolipids in bacterial cell wall and highlighted the involving mechanisms and biological application.
出处 《Green Chemical Engineering》 EI CSCD 2023年第4期417-426,共10页 绿色化学工程(英文)
基金 financial support from the National Natural Science Foundation of China(21676113,21772054) the 111 Project B17019,Scholar Support Program of CCNU(0900–31101090002) Excellent Doctorial Dissertation Cultivation Grant of CCNU from the colleges’basic research and operation of MOE(2019YBZZ029) funded by the Research Fund Program of Guangdong Key Laboratory of Radioactive and Rare Resource Utilization(2018B030322009) supported by Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules(KLSAOFM2012) Hubei University,Wuhan 430062,P.R.China,Opening fund of Hubei Key Laboratory of Bioinorganic Chemistry&Materia Medica(No.BCMM202101) supported by State Key Laboratory of Chemical Oncogenomics(Shenzhen)
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