结直肠癌患者口服卡培他滨化疗不同时期的服药依从性及其影响因素分析

The Compliance of Colorectal Cancer Patients at Different Oral Xeloda Chemotherapy Periods,and Its Influence Factors Analysis

目的:探讨结直肠癌患者口服卡培他滨化疗不同时期的服药依从性及其影响因素。方法:选取2021年1~12月于我院就诊并接受卡培他滨口服化疗的120例结直肠癌患者为观察对象,患者化疗初期(第1个周期)、中期(第4个周期)、末期(第8个周期)均接受Morisky服药依从性问卷、服药信念特异性问卷、癌症生活质量问卷调查,分析化疗不同时期患者的服药依从性及其影响因素。结果:本组共20例患者放弃服用药物,其中16例于化疗前3个周期内放弃用药。坚持用药的患者化疗初期、中期、末期服药依从性评分分别为(7.41±1.02)分、(6.94±1.09)分和(6.81±1.27)分,各期患者服药依从性评分比较差异有统计学意义,P<0.05。影响化疗用药初期服药依从性的因素主要有食欲丧失、服药信念和文化程度,影响用药中期服药依从性的因素主要有疲乏、造口与否,影响用药末期服药依从性的因素主要为居住地。结论:结直肠癌口服卡培他滨化疗前3个周期最易放弃服药,能坚持用药的患者服药依从性较好,但化疗不同时期患者用药依从性受不同因素影响,医护人员应有针对性予以护理干预。

Objective To investigate the compliance of colorectal cancer patients at different oral Xeloda chemotherapy periods,and the factors influencing it.Methods Enrolled 120patients with colorectal cancer treated in authors'hospital(2021-01-12),and received oral Xeloda chemotherapy into this study:at chemotherapy primary period(the first cycle),moderate(the fourth cycle),and end period(the 8th cycle)they all received Morisky questionnare about compliance to administering medicine,faith specificity of administering medicine,and cancer's quality of life,so as to analyse their compliance and the factors influencing it.Results In the 80cases,20abandoned taking durgs(16did so at the former 3cycles);in rest 60 patients persisted in taking drugs,the score ratings on compliance to taking drugs at primary,moderate and end periods was respectively(7.41±1.02)points,(6.94±1.09)points and(6.81±1.27)points,which there was statistical difference between the three periods(P<0.05).The factors influencing the compliance to taking drugs at primary period were mainly anorexia,faith of administering medicine,and educated levels;the factor at moderate period,fatigue,with or without receiving stomy;the factors at end period,the housing region.Conclusion At the former 3cycles of Xeloda chemotherapy,colorectal cancer patients are most easily to abandon to take drugs;the patients persising to take drugs have better compliance to taking drugs,but their compliance at different periods could be subject influence from different factors,for which medical staff should give them target nursing intervention.