甲苯磺酸瑞马唑仑联合舒芬太尼用于老年患者无痛结肠镜检查镇静的临床研究

Combination of Remazolam Toluenesulfonate and Sufentanial Applied in Sedation of Senior Patients Undergoing Painless Coloscopy:A Clinical Study

目的:探讨甲苯磺酸瑞马唑仑联合舒芬太尼用于老年患者无痛结肠镜检查镇静的效果。方法:选取2021年10月至2022年3月于我院接受无痛结肠镜检查的70例老年患者作为研究对象,根据随机数字表法分为对照组和观察组,每组35例。对照组缓慢静脉注射舒芬太尼+丙泊酚进行麻醉诱导,持续静脉泵注丙泊酚维持麻醉;观察组缓慢静脉注射舒芬太尼+甲苯磺酸瑞马唑仑进行麻醉诱导,持续静脉泵注甲苯磺酸瑞马唑仑维持麻醉。比较2组患者检查过程中不同时刻的心率(HR)、平均动脉压(MAP)、脉搏血氧饱和度(SpO_(2)),镇静成功率、麻醉苏醒时间及离院达标时间,以及不良事件发生情况。结果:2组镇静成功率均为100%;观察组患者麻醉苏醒时间及离院达标时间均明显短于对照组,P<0.05。2组患者麻醉诱导完成后,HR、MAP、SpO_(2)指标水平均呈先下降后上升的趋势;与对照组相比,观察组HR、MAP、SpO_(2)指标水平波动幅度更小。观察组低血压、呼吸抑制、头晕、恶心、呕吐、注射痛发生率均明显低于对照组,P<0.05。结论:与舒芬太尼联合丙泊酚镇静相比,甲苯磺酸瑞马唑仑联合舒芬太尼用于老年患者无痛结肠镜检查镇静效果与其相当,但后者对循环及呼吸系统影响更小,患者麻醉后苏醒更快、不良反应更少,安全性更高。

Objective To investigate the efficacy of remazolam toluenesulfonate plus sufentanial applied in sedation of senior patients undergoing painless coloscopy.Methods Randomly divided 70 senior patients received painless coloscopy in author’s hospital(2021-10-2022-03)into control group[35 cases,slowly injecting(sufentanial+propofol)as anesthesis revulsion,contionously pumping propofol to maintain anesthesia]and observation group[35 cases,slowly injecting(sufentanial+remazolam toluenesulfonate)as revulsion,continously pumping remazolam toluenesulfonate to maintain anesthesia];then,compared both groups’following items:HR,MAP and SpO_(2)at different time-points of inspection;sedation scuccess rate,emergence time,and the time set the standard discharged,as well as unward events status.Results Both groups’success rates were up to 100%,in the emergence time,and the time set the standard discharged observation group was all significantly shorter than control group(P<0.05);after revulsion both groups’HR,MAP,and SpO_(2)levels were all first declined,then uplifted,which observation group levels wave range was more less than control groups’one;in the incidence of low-blood pressure,respiratory suppression,dizziness,nausea,vomiting,and injecting pain,observation group was all significantly lower than control group(all,P<0.05).Conclusion Both sedation patterns for senior patients undergoing painless coloscopy and respiration system is more less,emergence is more faster,less unward reaction,and its safety is more higher.