育龄期多囊卵巢综合征患者体质指数与血脂异常的关系:一项横断面研究

The correlation between BMI and dyslipidemia in polycystic ovary syndrome patients of birth age in Chinese second babies′ times: a cross-sectional study

目的探究我国育龄期多囊卵巢综合征(PCOS)患者体质指数(BMI)与血脂异常的关系。方法选择符合纳排标准的213例患者。把研究人群根据血脂异常与否和BMI分别分为两组(血脂异常组与血脂正常组)及4组(BMI<18 kg/m^2为体重过低组,18 kg/m^2≤BMI<24 kg/m^2为体重正常组,24 kg/m^2≤BMI<28 kg/m^2为超重组;BMI≥28 kg/m^2为肥胖组),分析各组患者间的一般情况与各体脂指标和血脂异常率的阈值效应,用多元logistic回归分析BMI与血脂异常率的关系。结果体重过低组、体重正常组、超重组、肥胖组的血脂异常率分别为22.22%、39.58%、56.41%和60.00%。血脂异常率与各体脂指标的曲线拟合均呈直线正相关关系,无拐点。在调整了体脂率、内脏脂肪水平、腰围、臀围、腰臀比、空腹血糖、2 h血糖、空腹胰岛素、2 h胰岛素、糖化血红蛋白等指标后,与非超重/肥胖的PCOS患者相比,超重/肥胖的PCOS患者血脂异常的发生风险显著升高12.35倍(OR=12.35,95%CI=1.18~151.11,P=0.036)。结论育龄期PCOS患者的BMI与血脂异常率存在显著直线正相关关系,超重/肥胖的育龄期PCOS患者有更高的血脂异常风险。

Objective To investigate the correlation between BMI and dyslipidemia in patients with PCOS of birth age.Methods A total of 213 participants were enrolled.The participants were divided into two groups by dyslipidemia(dyslipidemia group and non-dyslipidemia group)or four groups by BMI(BMI<18 kg/m^2 for underweight group,18≤BMI<24 kg/m^2 for normal weight group,24≤BMI<28 kg/m^2 for overweight group;BMI≥28 kg/m^2 for obesity group).The general condition between various groups and the thresholds effect analysis of dyslipidemia prevalence and body fat indicators were analyzed.Multivariate logistic regression analysis was used to analyze the correlation between BMI and dyslipidemia prevalence.Results The prevalence of dyslipidemia in underweight group,normal weight group,overweight group and obesity group were 22.22%,39.58%,56.41%and 60.00%,respectively.Thresholds effect analysis suggested positive linear correlations of dyslipidemia prevalence with BMI,body fat index,waist and hips.After adjusting for BFI,visceral fat level,waist,hips,waist-to-hip ratio,fasting blood glucose,2-hour blood glucose,fasting insulin,2-hour insulin and glycosylated hemoglobin,overweight/obesity(OR=13.35,95%CI=1.18-151.11,P=0.036)were independently associated with dyslipidemia.Conclusion Our study demonstrated that there is a significant positive correlation between BMI and dyslipidemia in PCOS patients of birth age.Overweight/obesity PCOS patients have higher risk of dyslipidemia.