摘要
Creatinine level in urine is an important biomarker for renal function diseases,such as renal failure,glomerulonephritis,and chronic nephritis.The Au@MIL-101(Fe)was prepared by in situ growth of Au nanoparticles in MIL-101(Fe)as a selective SERS substrate.The Au@MIL-101(Fe)offers the great local surface plasmon resonance(SPR)effect due to gold nanoparticles aggre-gation inside metal-organic frameworks.The framework structure could enrich trace target samples and drag them into SPR hot spots.The optimal Au@MIL-101(Fe)composite substrate is used for analyzing creatinine in urine and the limit of detection is down to 0.1μmol/L and a linear relationship is ranging from 1μmol/L to 100μmol/L.
基金
We greatly appreciate the support of the National Natural Science Foundation of China(no.21475088)
the International Joint Laboratory on Resource Chemistry(IJLRC)
the Shanghai Key Laboratory of Rare Earth Functional Materials
Shanghai Engineering Research Center of Green Energy Chemical Engineering(18DZ2254200)
the Shanghai Municipal Education Comnfittee Key Laboratory of Molecular Imaging Probes and Sensors.
