摘要
Segmentation of layers in retinal images obtained by optical coherence tomography(OCT)has become an important clinical tool to diagnose ophthalmic diseases.However,due to the sus-ceptibility to speckle noise and shadow of blood vessels etc.,the layer segmentation technology based on a single image still fail to reach a satisfactory level.We propose a combination method of structure interpolation and lateral mean filtering(SI-LMF)to improve the signal-to-noise ratio based on one retinal image.Before performing one-dimensional lateral mean filtering to remove noise,structure interpolation was operated to eliminate thickness fluctuations.Then,we used boundary growth method to identify boundaries.Compared with existing segmentations,the method proposed in this paper requires less data and avoids the influence of microsaccade.The automatic segmentation method was verified on the spectral domain OCT volume images obtained from four normal objects,which successfully identified the boundaries of 10 physio-logical layers,consistent with the results based on the manual determination.
基金
This work was supported in part by National Natural Science Foundation of China(61771119 and 61901100)
Hebei Provincial Natural Science Foundation of China(H2018501087 and H2019501010)
Fundamental Research Funds for the Central Universities(N182304008).