心脏移植血管病变的发病机制及危险因素研究进展

Research progress in the pathogenesis and risk factors of cardiac allograft vasculopathy

目前心脏移植仍是治疗各种原因引起的终末期心脏病最有效手段.随着心脏移植受者生存期的延长,心脏移植血管病变(cardiac allograft vasculopathy,CAV)逐渐成为心脏移植受者远期并发症和死亡的主要原因之一.CAV的病理生理机制至今仍未完全阐明,多种免疫及非免疫机制可能参与了其过程.有关CAV的相关危险因素目前尚未达成一致意见.因此,本文将主要针对CAV的发病机制及危险因素进行综述.

At present,heart transplantation remains the most effective method for the treatment of end-stage heart disease caused by various causes.With the survival improvement of heart transplant recipients,cardiac allograft vasculopathy(CAV)has gradually become one of the main causes of long-term complications and death in heart transplant recipients.The pathophysiological mechanism of CAV has not yet been fully elucidated,and various immune and non-immune mechanisms may be involved in the process of its development.There are no consensus on the risk factors related to CAV.Thus,this paper will mainly review the pathogenesis and risk factors of CAV.