白细胞介素-10基因多态性与西藏地区慢性乙型肝炎的相关性研究被引量：1

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摘要目的观察中国藏族人群中白细胞介素-10(IL-10)基因多态性与慢性乙型肝炎(CHB)患者发病的相关性.方法选取藏族CHB患者113例及同期体检健康的藏族人群77例,通过实时定量荧光PCR及GeneAmp SDS软件检测IL-10-819位点的基因多态性.结果CHB组患者IL-10-819位点基因T/C多态性中,TT基因发生频次低于对照组(P<0.05),等位基因的发生频次差异无统计学意义(P>0.05).结论在中国藏族人群中,IL-10-819TT基因型的存在降低了HBV感染的风险,为藏族人HBV发病的保护性因素,IL-10-819基因多态性与藏族HBV的发病相关.

作者欧珠美朵嘎松卓嘎旦增

机构地区西藏自治区人民医院消化内科西藏自治区人民医院检验科

出处《山东大学学报（医学版）》 CAS 北大核心 2014年第S01期9-9,25,共2页 Journal of Shandong University:Health Sciences

关键词慢性乙型肝炎白细胞介素-10 实时定量荧光PCR 基因多态性

分类号 R394.3 [医药卫生—医学遗传学]

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