摘要
To accurately guide surgical instruments during ophthalmic procedures,some necessary intraoperative depth perception is required,which standard surgical microscopes supply limit-edly.Intraoperative optical coherence tomography(iOCT),combining optical coherence to-mography(OCT)technology and surgical microscope,enables noninvasive,real-time and high-resolution cross-sectional imaging.Currently,though iOCT enables structural imaging,little research has been done on intraoperative angiography.In this work,we presented a swept-source intraoperative OCT angiography(SS-iOCTA)system based on a standard surgical microscope,which provides both structural and angiographic images.The feasibility of the proposed SS-iOCTA was confirmed through deep anterior lamellar keratoplasty(DALK)of ex vivo porcine eyes and blood perfusion imaging of in vivo rat cortex.High-resolution intraoperative feedback,including sub-surface structure and angiogram of biological tissue,can be visualized simulta-neously with the SS-iOCTA system,which expand the surgeon's capabilities and could be widely used in clinical surgery.
基金
National Natural Science Foundation of China(62075189 and 81873911)
Zhejiang Provincial Natural Science Foundation of China(LR19F050002)
Zhejiang Lab(2018EBOZX01)
Fundamental Research Funds for the Central Universities(2018FZA5003).