血清GHbA1c、Cys C、NLR与冠状动脉粥样硬化狭窄程度的相关性分析

The correlation analysis o between serum levels of GHbA1c, Cys C, NLR and severity of coronary atherosclerotic stenosis

目的:探究血清中GHbA1c、Cys C、NLR和冠状动脉粥样硬化狭窄程度的相关性。方法:选择2017年1月~2019年1月在我院心血管内科住院治疗的冠状动脉粥样硬化患者即病例组98例,将同期住院冠状动脉造影提示冠状动脉未见明显狭窄者设为对照组,共80例。将病例组根据Gensini评分进行分组,对比分析血清糖化血红蛋白(GHbA1c)、胱抑素C(Cys C)、中性粒细胞淋巴细胞比值(NLR)水平。结果:病例组的血清GHbA1c和NLR水平高于对照组,但Cys C水平低于对照组,差异具有统计学意义;重度组的血清HbA1c和NLR水平均高于轻度组和中度组,但Cys C均低于轻度组和中度组,差异均具有统计学意义;中度组的Cys C低于轻度组,差异具有统计学意义。血清GHbA1c及NLR与Gensini评分均呈正相关,与Cys C呈负相关,均有统计学意义。经Logistic回归分析发现有高血压病史和、糖尿病病史、高水平的TG、TC、GHbA1c为冠状动脉粥样硬化发生的独立危险因素。结论:血清GHbA1c、Cys C和NLR水平与冠状动脉粥样硬化狭窄程度的有极大的相关性,也是冠状动脉粥样硬化的重要危险因素。

Objective To explore the correlation between serum levels of glycosylated hemoglobin(GHbA1c),cystatin C(Cys C)and neutrophil lymphocyte ratio(NLR)and the severity of coronary atherosclerotic stenosis.Methods 98 patients with coronary atherosclerosis who were hospitalized in the department of cardiovascular internal medicine between January 2017 and January 2019 in our hospital were selected as the case group,and 80 patients whose coronary angiography showed no obvious stenosis during the same period were taken as the control group.The patients were divided into groups according to the score of Gensini,and the levels of serum glycosylated hemoglobin(GHbA1c),cystatin C(Cys C),neutrophil lymphocyte ratio(NLR)were compared and analyzed.Results The levels of GHbA1c and NLR in the case group were higher than those in the control group,however,the level of Cys C was lower than that in the control group.The levels of HbA1c and NLR in the severe group were higher than those in the mild group and the moderate group,but the level of Cys C was lower than that in the mild group and the moderate group.The levels of Cys C Hcy in the moderate group was lower than that in the mild group.The serum levels of GHbA1c and NLR were positively correlated with Gensini score,while Cys C was negative corelation.Logistic regression analysis showed that hypertension,diabetes,high levels of TG,TC and GHbA1c were independent risk factors for coronary atherosclerosis.Conclusion The serum levels of GHbA1c,Cys C and NLR are highly correlated with the severity of coronary atherosclerotic stenosis,and they are risk for the coronary atherosclerosis.