凝血四项、血清TNF-α及D-D在子痫前期患者中的临床诊断意义

The clinical detective value of blood clotting four item, the serum TNF-α and D-D in the patients with preeclampsia eclampsia

目的:探析凝血四项如凝血酶时间(TT)、活化部分凝血酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、血清肿瘤坏死因子-α(TNF-α)、D-二聚体(D-D)在子痫前期(PE)患者中的临床诊断价值及其相关性。方法:选取2016年10~2018年10月在我院妇产科接受诊治的40例轻度PE患者和40例重度PE患者(包括16例并发症患者和24例无并发症患者)作为本次研究的A组和B组。另外选取同期在我院产科正常分娩的40例孕产妇作为本次研究的C组。比较三组患者的基线资料、凝血四项、血清TNF-α及D-D水平。比较有无并发症组间的凝血四项、血清TNF-α及D-D水平。相关性分析PE患者凝血四项、血清TNF-α及D-D水平。结果:三患者的基线资料无明显统计学差异。A、B组患者的TT、FIB、TNF-α、D-D水平明显高于C组,A、C组患者的APTT、PT水平明显高于B组,且A组患者的APTT、PT水平明显高于B组,而TNF-α、D-D水平明显低于B组。并发症组患者的FIB、TNF-α、D-D水平明显高于无并发症组患者。PE患者的D-D水平与FIB、血清TNF-α水平均存在显著正相关性。结论:联合动态监测凝血指标、TNF-α及D-D水平在PE患者的诊断及病情预估方面具有重要作用。

Objective To analyze the clinical detective value of blood clotting four item such as TT,APTT,PT,FIB and the serum TNF-α,D-D in the patients with preeclampsia eclampsia(PE)and the relationship between TT,APTT,PT,FIB and the serum TNF-α,D-D.Methods 40 patients with mild PE and 40 patients with serve PE(including 16 complication patients and 24 non-complication patients)received treatment at our hospital from October,2016 to October,2018 were chosen as the group A and group B in this research.40 pregnant women with normal delivery at the same time at our hospital were chosen as the group C in this research.The general information,the levels of blood clotting four item,the serum TNF-αand D-D in three groups were compared.The relationship between TT,APTT,PT,FIB and the serum TNF-α,D-D in PE patients was analyzed.Results The general information in three groups had no statistical difference.The levels of TT,FIB,TNF-α,D-D in group A and B were obviously higher than those in group C,the levels of APTT and PT in group A and C were obviously higher than those in group B,and the levels of APTT and PT in group A were obviously higher than those in group B,and the levels of TNF-α,D-D in group A were obviously lower than those in group B.The levels of FIB,TNF-α,D-D in complication group were obviously higher than those in non-complication group.The levels of D-D had obvious positive correlation with FIB and TNF-αin PE patients.Conclusion The dynamic monitoring of blood clotting four item combined with TNF-αand D-D has important value on detection and disease prediction of PE patients.