摘要
Photodynamic therapy(PDT)takes advantage of photosensitizers(PSs)to generate reactive oxygen species(ROS)for cell killing when excited by light.It has been widely used in clinic for therapy of multiple cancers.Currently,all the FDA-approved PSs,including porphyrin,are all small organic molecules,suffering from aggregation-caused quenching(ACQ)issues in biological environment and lacking tumor targeting capability.Nanoparticles(NPs)with size between 20 nm and 200 nm possess tumor targeting capability due to the enhanced permeability and retention(EPR)effect.It is urgent to develop a new strategy to form clinical-approved-PSs-based NPs with improved ROS generation capability.In this study,we report a strategy to overwhelm the ACQ of porphyrin by doping it with a type of aggregation-induced emission(AIE)luminogen to produce a binary NPs with high biocompatibility,and enhanced fluorescence and ROS generation capability.Such NPs can be readily synthesized by mixing a porphyrin derivative,Ce6 with a typical AIE luminogen,TPE-Br.Here,our experimental results have demonstrated the feasibility and effectiveness of this strategy,endowing it a great potential in clinical applications.
基金
This work was supported by the National Nature Science Foundation of China(Grant Nos.61425006,61227017 and 81573382)
the National Key Research and Development Program of China(2019YFC1604604)
Program of Shanghai Technology Research Leader(Grant No.17XD1402200)
Shanghai Jiao Tong University(ZH2018QNA43)
Open Project Program of Wuhan National Laboratory for Optoelectronics(2019WNLOKF019).
