第二原发性肺癌风险预测的研究进展

Research progress in risk prediction of second primary lung cancer

第二原发性肺癌(second primary lung cancer,SPLC)的发病率和检出率逐年升高。SPLC的发病机制尚不明确,目前也没有任何筛查指南涉及如何监测SPLC的发展。SPLC的发病风险有持续性,初始原发性肺癌的诊断年龄,病理类型,肿瘤分期以及是否放疗等是SPLC发病的预测因素,SPLC发病间隔越长,分期越早的患者预后越好。吸烟和基因等因素对SPLC发病的影响仍需进一步研究。

The incidence and detection rate of second primary lung cancer(SPLC)increased year by year.The pathogenesis of SPLC is unclear,and there is currently no screening guideline for monitoring the development of SPLC.There is a continued risk for development of SPLC,and the diagnosis age,pathological type,tumor stage and whether or not received radiotherapy of the initial primary lung cancer are the predictors of SPLC.The longer the lung cancer interval and the earlier tumor stage of the patients will lead to the better prognosis.Further researches need to be carried out to explore the effects of smoking and genetics on the development of SPLC.