脑转移瘤治疗的临床进展及新思考

New strategies and ideas for treatment of brain metastasis

脑转移瘤是成年人颅内最常见的恶性肿瘤.大约20%~40%的各种恶性肿瘤患者在疾病的不同时期发生脑转移,脑转移瘤已经是导致肿瘤患者死亡的最主要的原因之一.如何合理治疗脑转移瘤以达到改善生存质量及延长生存期已成为目前临床研究的热点.近年来,随着人们对脑转移瘤基础及临床研究的逐渐深入,除了传统的放射治疗及手术的技术有明显的提高,新的治疗技术如靶向治疗,抗血管生成治疗及免疫检查点抑制剂等治疗方式层出不穷,脑转移瘤治疗的有效率不断提高,患者的生存期明显延长.本文对目前的新的临床实验进行简要介绍.

Brain metastases are the most common malignant tumors in adults.About 20%-40%of all malignant tumors occur brain metastasis at different stages of the disease.Brain metastasis has been one of the main causes of death of cancer patients.How to treat brain metastases reasonably in order to improve the quality of life and prolong the survival time has become a hot topic in clinical research.In recent years,with the gradual deepening of basic and clinical research on brain metastases,in addition to the traditional radiotherapy and surgical techniques,new treatment strategies such as targeted therapy,anti-angiogenesis therapy and immunological checkpoint inhibitors have emerged in endlessly.The efficiency of brain metastases treatment has been continuously improved,and the survival of patients has been significantly prolonged.This article briefly introduces the current new clinical trials.