广东省四会市1976-2005年1761例鼻咽癌患者的生存率分析

A survival analysis of 1761 nasopharyngeal carcinoma cases diagnosed during 1976-2005 in Sihui city in Gnangdong province

目的为分析四会市鼻咽癌生存率和评价高发现场30年肿瘤防治效果.方法在四会市肿瘤发病登记制度和死因登记制度的基础上,收集了1761例鼻咽癌患者的随访资料.统计指标包括5、10年生存率和中位生存时间,Cox回归用于分析独立的预后因素.结果四会市人群鼻咽癌5和10年生存率分别为50.62%和37.01%,中位生存时间为5.05年.1993年后诊断的患者5年生存率为58.8%,比1993年以前诊断患者的5年生存率43.3%有明显改善.其他与预后有关的因素包括性别、年龄、临床分期和诊断医院.结论四会市鼻咽癌患者的生存率有明显改善,主要与治疗水平提高有关.而鼻咽癌死亡率的下降仍需要长期观察.

Objectives To analyze the survival rate of nasopharyngeal carcinoma(NPC)and to evaluate the effect of intervention in this high risk population of NPC.Methods Based on the cancer and vital registry systems,the fllw up data of 1761 NPC cases were cllctede The measures of survival include 5-year,10-year survival rate and median survival duration.Cox model was used to screen the independent prognosis factors.Results The 5-year and 10-year survival rates of NPC cases in Sihui were 50.62%and 37.01%,and the median survival duration was 5.05 years.The survival rate of NPC cases diagnosed after 1993 was 58.8%,which was higher than that of cases diagnosed before 1993(43.3%).Other prognosis factors included gender,age,clinical stage and diagnostic hospital.Conclusion There is a significant improvement of NPC survival in Sihui.That is mainly related to the improvement of NPC treatment.However,it needs to a long time observation to see a mortality reduction of NPC.