口腔念珠菌感染对口腔白斑癌变的作用

The effect of oral candida to development of oral leukoplakia into cancer

目的探讨正常人、口腔白斑、口腔鳞状细胞癌的唾液培养真菌检出率,以阐明口腔念珠菌对口腔白斑癌变的作用.方法采用唾液培养法,检测100名健康对照者、110例口腔白斑及11例鳞癌患者口腔念珠菌的感染情况.并记录受试者吸烟情况.进行卡方检验、双变量相关分析和二项分类logistic回归分析.结果显示口腔白斑的恶性度与其唾液真菌培养阳性率相关(r=0.148,P=0.032).唾液真菌培养结果与受试者的病理分型相关(x^(2)=21.757,P=0.010).唾液真菌培养结果与受试者的年龄和烟龄相关(OR_(年龄)=0.72,P_(年龄)=0.000;OR_(烟龄)=0.37,P_(烟龄)=0.01).结论念珠菌感染很可能是促进上皮异常增生及白斑癌变的重要因素之一,临床上发现白斑患者应常规做唾液培养,并加强对白斑伴念珠菌感染患者的随访.

Objective To investigate the rate of candidal infection in different condition of oral epithelia,that may imply the possibility of candida in the canceration of oral leukoplakia Methods Saliva culture was used to detect the infection of candida in 100 cases of healthy control group,110 cases of oral leukoplakia and 11 cases of oral squamous cell carcinoma,whose smoking condition were collected carefully.The results were analyzed by Crostabs,Bivariate Correlations and Binary Logistic Regression analysis.Results With Crostabs and Bivariate Correlations analysis,there was significant correlation within malignant level of oral leukoplakias and candidal infection rates(r=0.148,P=0.032).With Crostabs single factor analysis,there was signifcant correlation within saliva culture results and pathological types(X^(2)=21.757,P=0.010).With Binary Logistic Regression analysis,there was significant correlation within saliva culture results and both of subjects,ages(OR=0.72,P=0.000)and duration of smoking(OR=0.37,P=0.01).Conclusion Candidal infection may be one of the most important factors inducing dysplasia of epithelia and malignant transformation of oral leukoplakia So saliva culture should be taken 88 a rule for patients with oral leukoplakia.The follow-up of oral leukoplakia patients with candidal infection should be enhanced.