人乳头状瘤病毒在河南省农村妇女中的感染情况

Human papillomaviruses infections among village women in Henan province

目的在我国河南省农村地区调查妇女高危型人乳头状瘤病毒(human papillomavirus,HPV)的感染情况,并探讨与人乳头状瘤病毒感染有关的危险因素.方法对河南省新密市的农村妇女(881名)开展以人群为基础的子宫颈癌横断面调查,分析其中20~54岁有性生活史的女性.使用自我取样和医生取样2种方法收集妇女阴道分泌物,使用杂交捕获二代试验(hybrid capture 2,HC2)检测标本13种高危型HPV感染情况.对结果异常的妇女进行阴道镜及活组织病理检查,最终以病理诊断结果作为金标准.结果共调查妇女881名,收集HPV自我取样标本881份和医生取样标本880份.自我取样和医生取样HPVs感染率分别是13.05%和12.27%.各个年龄组(20岁~、25岁~、30岁~、35岁~、40岁~、45岁~、50~54岁)HPVs感染率分别是10.57%、9.60%、12.00%、9.52%、17.60%、13.74%、12.80%.随着宫颈病变程度增加HPV感染率呈上升趋势(X^(2)=200.69,P=0.00);随着教育水平的提高HPV感染率逐渐增加(X^(2)=11.05,P=0.01);丈夫性伴侣数>1的妇女HPV感染率是18.02%,丈夫性伴侣数为1的妇女HPV感染率是10.88%,差异有统计学意义(X^(2)=6.37,P=0.01).结论该地区的高危型HPV感染率较高,HPV感染与年龄无关,性行为是其主要危险因素.

Objective To investigate the prevalence of Human papillomaviruses(HPVs)among village women in Henan and to determine its relevant risk factors.Methods A population based cross-sectional study on cervical cancer was conducted among vllage women in Xinmi,Henan.Women aged 20-54 who had sexual intercourse experiences were enolled in this study.Self-sampling and direct-sampling were used in cllecting women's vaginal discharge.13 high-risk HPVs were tested with HC2 for all of the specimens.Then women with abnormal results did colposcopy and biopsy.The biopsy results were regarded as the golden standard.Results There were 881 women enolled in this paper and 881 sel-8ampling and 880 direct-sampling specimens were colleted.The HPVs prevalence rates for the self-sampling and direct-sampling were 13.05%and 12.27%,respectively.Age-specific prevalence rates were 10.57%(20-),9.60%(25-),12.00%(30-),9.52%(35-),17.60%(40-),13.74%(45-)and 12.80%(50-54).HPV prevalence rates were increased with progression of cervical disease(X^(2)=200.69,P=0.00).And HPV prevalence rates were higher in women with more advanced education background(X^(2)=11.05,P=0.01).HPV infection rate in women whose husbands have more than one sexual partner was 18.02%and whose husbands have only one sexual partner was10.88%(X^(2)=6.37,P=0.01).Conclusion The infection rate of high-risk HPVs in this area is high.The relatiohsip of HPV infection with age has not been observed in this study,but the the sexual activity is the major risk factor for cervical cancer.