卡前列素氨丁三醇联合卡前列甲酯栓预防剖宫产患者产后出血的价值

The Value of Carboprost Tromethamine Combined with Carboprost Methyl Ester Suppository in the Prevention of Postpartum Hemorrhage in Patients Undergoing Cesarean Section

目的研究卡前列素氨丁三醇联合卡前列甲酯栓预防剖宫产产后出血的价值.方法选取我院妇产科2020年1月-2020年12月收入的100例产妇为研究对象,随机分为对照组和实验组,各组50例.对照组采取卡前列酯栓,实验组在对照组基础上联合卡前列素氨丁三醇,观察比较两组产后不同时间出血量、红蛋白、红细胞、红细胞比容、凝血功能指标以及不良反应发生率.结果实验组产后2h、24h出血量均小于对照组(P<0.05);实验组红蛋白、红细胞、红细胞比容均大于对照组(P<0.05);实验组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)均小于对照组(P<0.05);实验组不良反应发生率10.00%与对照组12.00%比较(P>0.05).结论卡前列甲酯栓联合卡前列素氨丁三醇可减少剖宫产患者产后出血量,改善红蛋白、红细胞、红细胞比容以及凝血功能指标,且不会增加不良反应发生率,是一种安全、有效的预防方案.

Objective To study the value of carboprost tromethamine combined with carboprost methyl ester suppository in the prevention of postpartum hemorrhage after cesarean section.Methods 100 parturients from January 2020 to December 2020 were randomly divided into control group(n=50)and experimental group(n=50).The control group was treated with Carboprost suppository,the experimental group was treated with carboprost combined with tromethamine on the basis of the control group,the amount of postpartum bleeding,hemoglobin,red blood cells,hematocrit,coagulation parameters and the incidence of adverse events were observed and compared between the two groups.Results The amount of bleeding at 2 h and 24 h after delivery in the experimental group was less than that in the control group(P<0.05),and the hemoglobin,red blood cells and hematocrit in the experimental group were more than those in the control group(P<0.05);The prothrombin time(PT)and activated partial thromboplastin time(APTT)in the experimental group were lower than those in the control group(P<0.05),and the incidence of adverse reactions in the experimental group was 10.00%as compared with 12.00%in the control group(P<0.05).Conclusion The combination of carboprost methyl ester suppository and carboprost tromethamine can reduce postpartum hemorrhage,improve hemoglobin,red blood cell,hematocrit and coagulation parameters in caesarean section patients,and will not increase the incidence of adverse reactions,is a safe and effective prevention program.