基于胰腺癌防治现状的思考

Thoughts on the current situation of pancreatic cancer prevention and treatment

胰腺癌在全球范围内发病率和死亡率均逐年增高,但防治效果很不理想。胰腺癌病因不明确,预防困难,辅助检测手段的灵敏度和特异度低,早期诊断是世界性难题。现有的治疗手段疗效不满意,且短期内难以突破。基于胰腺癌防治现状,需加强基础研究、探究其病因和发病机制,去除病因、切断发生发展路径;研发高灵敏度、高特异度的外周血和尿液等检测技术以及影像诊断技术以提高早期诊断率和疗效;规范多学科综合治疗,优化组合现有的诊疗方法,制定个性化的治疗方案,达到改善疗效的目的。

It is noticeable that the incidence and mortality of pancreatic cancer are growing every year worldwide.However,the effectiveness of prevention and control is not ideal.Considering that primary prevention of pancreatic cancer is difficult and the sensitivity and specificity of auxiliary examinations are low,the early diagnosis is still a difficult problem for the entire world.Current strategies for treatment are unsatisfactory,and making breakthrough is difficult in a short term.Based on the current status of pancreatic cancer prevention and treatment,it is necessary to strengthen basic research,explore its etiology and pathogenesis,eliminate the causes and cut off the approach of occurrence and development.To develop high-sensitivity and high-specificity detection methods such as peripheral blood and urine analysis,as well as imaging diagnostic technologies,can improve the early diagnosis rate and efficacy.Standardized multidisciplinary therapy,optimized combination of diagnosis and treatment methods,and personalized plans should be implemented to achieve the goal of improving curative effects for pancreatic cancer.