Single nucleotide polymorphism rs11191454 in arsenite methyltransferase is associated with flow in Chinese students:a genetic study on flow experience

Flow has been widely studied in the field of positive psychology.However,little is known regarding its biological mechanism.This study aimed to ascertain flow-related gene loci.We investigated the association between flow and five single nucleotide polymorphisms associated with common mental disorders among a sample of 870 healthy 1 st year students of Jining Medical University,Shandong Province,China.This study was approved by the Ethics Committee of Jining Medical University(approval number:JNMC-2016-KY-001)on June 1,2016.rs11191454 demonstrated significant statistical association with flow after adjusting for age and gender(P=0.004).The allele carriers achieved higher scores in all 4 dimensions of flow:merging of action and awareness,challenge-skill balance,sense of control,and clear goals.This biological research article indicates that rs11191454 in the arsenite methyltransferase(AS3MT)gene might be associated with flow in a Chinese Han population,and that might result from altered arsenic metabolism.