摘要
Schizophrenia is a life-long,complex mental illness that still lacks satisfactory treatments.In recent years,increasing numbers of candidate biomarkers of schizophrenia occurrences and drug responses to schizophrenia therapies have been successfully identified by many omics studies.This review discusses the latest discoveries regarding effective drug targets and relevant drug classifications in schizophrenia.It also assesses our understanding of biomarkers for drug efficacy and adverse drug reactions in current schizophrenia treatments using omics technologies.Future applications in clinical practice have been proposed based on these new findings,and are now considered highly promising strategies to better treat schizophrenia.Finally,we explore several novel approaches that aim to reveal additional genetic signatures of schizophrenia using multi-omics data,which are hoped to improve the diagnosis and treatment of this illness in the future.
基金
This work was supported by grants from the 863 Program(No.2012AA02A515,2012AA021802)
the National Natural Science Foundation of China(No.81773818,81273596,30900799,81671326)
the National Key Research and Development Program of China(No.2017YFC0909303,2016YFC0905000,2016YFC0905002,2016YFC1200200,2016YFC0906400)
the 4th Three-year Action Plan for Public Health of Shanghai,China(No.15GWZK0101)
Shanghai Pujiang Program,China(No.17PJD020)
Shanghai Key Laboratory of Psychotic Disorders,China(No.13dz2260500).
