摘要
Many common diseases are characterized by polygenic architectures in which a single variant has only a small effect on phenotype.Genome-wide association studies and next generation sequencing have identified thousands of genetic variants of disease susceptibility.Recently,non-coding variants identified by genome-wide association studies have been systematically reviewed.Here,we review disease-causing coding variants and their relevance to clinical medicine.
基金
This work was financially supported by the National Natural Science Foundation of China(No.81130031).