摘要
Background:Inflammatory bowel diseases(IBDs)are a group of chronic diseases affecting the gastrointestinal tract,with a disabling course.The incidence of IBDs is increasing in different geographical areas,indicating its emergence as a global disease,especially in children.Many patients with IBDs develop extraintestinal manifestations(EIMs)during follow-up,as IBDs have a potential risk of systemic involvement..Data sources:A systematic review of the literature was made to analyze latest studies on pancreatic involvement in children with IBD including our experience in assessing possible implications and its future application.Results:The involvement of the hepatobiliary system is considered a rare EIM of children with IBD,with an incidence much higher than that in the general population.Isolated pancreatic hyperenzymemia,which occurs in the absence of typical symptoms and/or characteristic imaging findings,may be found in many patients with IBD.The frequent causes of pancreatitis are drugs,bilio-pancreatic disorders,immunologic disturbances and pancreatic auto-antibodies,although in some cases idiopathic forms have been described.Conclusions:It is important to establish a correct diagnostic approach based on etiology and to assess the most appropriate therapeutic strategy,thus avoiding complications and improving the quality of life of children with IBD.
