摘要
Background:Neuroblastoma(NB)is the most common extracranial solid tumor in childhood and displays remarkable heterogeneity in clinical behaviors,ranging from spontaneous regression to rapid progression or resistance to multimodal treatment.Recent evidence has shown that microRNAs(miRNAs),a class of small non-coding RNAs,are involved in tumor development and progression.This article aimed to review recent advances in investigating the roles of miRNAs in NB.Methods:We searched the PubMed/MEDLINE database for articles about the expression profile,functions and target genes of miRNAs in NB.Results:We reviewed the most recent evidence regarding the functional roles of oncogenic and tumor suppressive miRNAs in NB and application of novel miRNA-based methods for diagnostic,prognostic and therapeutic purposes.Conclusions:Deregulation of miRNAs is associated with the development and progression of NB,suggesting that miRNAs may serve as novel targets for the treatment of high-risk NB patients.However,their precise functions and underlying mechanisms still warrant further studies.
基金
supported by grants from the National Natural Science Foundation of China(30772359,81071997,81072073,81272779,81372667)
Program for New Century Excellent Talents in University(NCET-06-0641)
Scientific Research Foundation for the Returned Overseas Chinese Scholars(2008-889)
Research Fund for the Central University(2012QN224,2013ZHYX003)
