摘要
肠缺血再灌注损伤(IRI)是临床上常见的急危重症,发病率和死亡率均较高.目前对肠IRI的基础研究得到广泛关注,而成功地构建肠IRI动物模型是开展基础研究的基础,夹闭肠系膜上动脉的肠IRI动物模型应用最为广泛.本文详细阐述了夹闭肠系膜上动脉的小鼠肠IRI模型的构建过程及注意事项,将有助于提高小鼠肠IRI模型构建的成功率,从而助推肠IRI的动物体内研究.
Intestinal ischemia reperfusion injury(IRI)is a common clinical emergency with high morbidity and mortality.Mechanistic studies of intestinal IRI have received extensive attention,and the successful construction of an animal model of intestinal IRI is the basis for basic research.The rodent animal model of clamped superior mesenteric artery is a widely used animal model of intestinal IRI.This article describes in detail the process of constructing a mice model of intestinal IRI by clamping the superior mesenteric artery and the precautions to be taken.It will help to regulate the construction of the mice model of intestinal IRI and improve the success of the model construction,thus contributing to the basic research of intestinal IRI.
作者
刘婷婷
田丰
贾中芝
LIU Tingting;TIAN Feng;JIA Zhongzhi(Graduate College of Dalian Medical University,Dalian,Liaoning 116044,China;Department of Interventional and Vascular Surgery,the Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University,Changzhou,Jiangsu 213000,China)
出处
《手术电子杂志》
2024年第1期11-14,共4页
Electronic Journal of Medical Operations
基金
中国博士后科学基金(2023M730371)
南京医科大学常州医学中心项目(CMCC202206,CMCB202304)
关键词
小鼠
肠
缺血再灌注损伤
模型
mouse
intestinal
ischemia reperfusion injury
model
