妊娠期镇静催眠药物的合理应用

Rational application of sedative-hypnotic drugs in pregnancy

受医学伦理学等多方面因素的影响,关于妊娠期用药安全性问题的研究迄今仍不充分。失眠是妊娠期常见的情况,既可能是怀孕后正常的生理表现,也可能是精神疾病的一个早期症状,或是导致精神疾病复发的诱因。然而,目前有关孕期使用镇静催眠药物的安全性研究大部分为小样本回顾性研究,研究结果缺乏一致性,因此安全性有待进一步证实。现就妊娠期镇静催眠药物应用安全性的现有研究进行综述。

Under the influence of medical ethics and other factors,the safety of medication in pregnancy has not been fully studied so far.Insomnia is a common condition during pregnancy.It may be a normal physiological manifestation after pregnancy,an early symptom of mental illness,or an inducement to relapse of mental illness.However,most of the current safety studies on the use of sedative hypnotics during pregnancy are small sample retrospective studies,and the results are inconsistent.Therefore,its safety needs to be further confirmed.This paper reviews the existing researches on the safety of sedative hypnotics in pregnancy.