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髓系树突状细胞参与肾缺血再灌注所致急性肾损伤的研究进展 被引量:1

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摘要 树突状细胞(dendritic cell,DC)是已知能力最强的抗原提呈细胞(antigen presenting cell,APC).人体中存在多种来源的DC,髓系树突状细胞(bone marrow-derived dendritic cells,BMDCs)是免疫系统中重要的细胞群之一,在肾脏急性肾损伤(acute kidney injury,AKI)发生时,BMDCs可以作为抗原提呈细胞激活初始T细胞,同时作为分泌肿瘤坏死因子(tumor necrosis factor,TNF-α)以及白细胞介素-10(interleukin-10,IL-10)等细胞因子影响炎性细胞浸润程度.BMDCs对炎性损伤以及肾脏组织修复具有促炎和抑炎的两重作用.AKI是一种常见的临床综合征,后期易进展为慢性肾病(chronic kidney disease,CKD),甚至终末期肾病(end stage renal disease,ESRD).近年来AKI的发生率明显呈上升趋势,全球每年约有1300余万例AKI患者,其中约170万例患者死亡.缺血再灌注损伤(ischemia reperfusion injury,IRI)是AKI的主要风险因素之一.
作者 安哲昆 蔡明
出处 《泌尿外科杂志(电子版)》 2021年第3期98-100,104,共4页 Journal of Urology for Clinicians(Electronic Version)
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