摘要
目的:了解某肿瘤专科医院抗肿瘤药物超说明书用药现状与特点。方法:依据医院临床超说明书用药备案表,统计抗肿瘤药物在适应证、剂量方案、给药途径超说明书用药的比例,结合临床申报的具体情况进行分析。结果:从药物种类分析,化疗药物与靶向药物超说明书用药比例最高,分别为78.1%与20.0%;从超说明书用药类型分析,适应证超说明书最多,比例为97.8%,给药剂量与给药途径超说明书用药分别为42.2%与10.0%。结论:化疗药物与靶向药物的超说明书用药最普遍,类型以适应证超说明书用药最常见,需予以重点跟踪分析。
Objective:To investigate the characteristics of the off-label use of anti-cancer drugs in a cancer hospital.Methods:Based on the results of off-label medication use in Peking University Cancer Hospital,the ratio of off-label use in indication,dosage regimen and route of administration were colected and analyzed.Results:In the analysis of drug category in the anti-cancer drug off-label use,chemotherapy and target agents accounted for the greatest proportion,which were 78.1%and 20.0%respectively.Indication off-label use ranks first with the proportion of 97.8%,folowed by dosage and administration route off-label use,which are 42.4%and 10.0%respectively.Conclusion:Chemotherapy and targeted drugs are the most common ones in anti-cancer drug off-label use,mostly exhibiting as indication off-label medication,and these areas should be focused and analyzed.
作者
焦园园
王丹
张关敏
李然
马旭
刘颖
刘红
郭子寒
赵明月
薛冬
邢沫
张艳华
JIAO Yuan-yuan;WANG Dan;ZHANG Guan-min;LI Ran;MA Xu;LIU Ying;LIU Hong;GUO Zihan;ZHAO Ming-yue;XUE Dong;XING Mo;ZHANG Yan-hua(Department of Pharmacy,Peking University CancerHospital&Institute,Key laboratory of Carcinogenesis and Translational Research(Ministry of Education),Beijing 100142,China;Medical Administration Division,Peking University CancerHospital&Institute,Key laboratory of Carcinogenesis and Translational Research(Ministry of Education),Beijing 100142,China;Department of integrated traditional Chinese and Western Medicine,Peking University CancerHospital&Institute,Key laboratory of Carcinogenesis and Translational Research(Ministry of Education),Beijing 100142,China;Department of Pharmacy administration and clinical pharmacy,Peking University School of Medicine,Beijing 100191,China)
出处
《临床药物治疗杂志》
2014年第S01期35-38,共4页
Clinical Medication Journal
