不同生活方式对胃食管反流病的影响:一项基于37442例中国成年人的Gerd Q量表评分横断面研究

Association Between Lifestyle and Gastroesophageal Reflux Disease Questionnaire Scores:A Cross-Sectional Study of 37442 Chinese Adults

目的:研究中国体检人群中Gerd Q量表评分结果的分布特征及生活方式与Gerd Q量表评分之间的关系.方法:收集2009年9月至2016年3月之间的37442名健康体检对象,记录人口学基本信息、吸烟和饮酒嗜好,饮食习惯和运动习惯,以及体格检查和实验室指标,填写Gerd Q量表;按照Gerd Q积分将研究对象分为两组,即疑似GERD组和非GERD组.对比两组性别、年龄,以及其他指标的分布差异.结果:Gerd Q评分≥8分的占19.89%(7449/37442人),Gerd Q评分<8分的占80.11%(29993/37442人),男性疑似胃食管反流病的患病率明显高于女性(χ^(2)=111.571,P<0.001),中青年疑似胃食管反流病的患病率高于老年.疑似胃食管反流病患病率随体重增加而逐渐增加(χ^(2)=145.227,P<0.001).在生活方式方面,吸烟(χ^(2)=119.361,P<0.001)、过度饮酒(χ^(2)=211.635,P<0.001)、缺乏体力活动(χ^(2)=86.916,P<0.001)、摄入过多的油、肉、鱼、蛋增加疑似胃食管反流病的患病率(χ^(2)=105.388,P<0.001),而适量摄入蔬菜(≥300 g/d)和水果(≥200 g/d)可显著降低疑似胃食管反流病的患病率.结论:疑似胃食管反流病见于19.89%的健康体检个体中,不良生活方式与疑似GERD的高发密切相关,Gerd Q评分可在GERD筛查中发挥重要的作用.

Objectives:The aim of this study was to investigate the distribution characteristics of Gerd Q results in a Chinese population and the association between lifestyle and Gerd Q scores.Methods:37442 healthy subjects from September 2009 to March 2016 were enrolled.Basic demographic information,smoking and drinking habits,eating habits and exercise habits,as well as physical examination and laboratory indicators were recorded and filled in Gerd Q scale.According to Gerd Q score,the subjects were divided into two groups,namely suspected GERD group and non GERD group.The differences of gender,age and other indicators were compared between the two groups.Results:7449(19.89%)had a Gerd Q score of≥8 points and 29993(80.11%)had a Gerd Q score of<8 points.The percentage of men with suspected GERD was significantly higher than the percentage of women with suspected GERD(χ^(2)=111.571,P<0.001),and the prevalence of GERD was higher in the young and middle-aged populations than in the elderly population.The prevalence of GERD increased gradually with weight gain(χ^(2)=145.227,P<0.001).With regard to lifestyle,the prevalence of GERD in the subjects who smoked(χ^(2)=119.361,P<0.001),consumed alcohol excessively,lacked physical activity(χ^(2)=86.916,P<0.001),and had an excessive intake of oil,meat,fish,and eggs showed an ascending trend(χ^(2)=105.388,P<0.001).In contrast,an adequate intake of vegetables(≥300 g/d)and fruit(≥200 g/d)was associated with a significantly lower incidence of GERD.Conclusions:Suspected GERD is very common in individuals undergoing health examinations.Unhealthy lifestyles are closely related to the high incidence of suspected GERD.Gerd Q scores can play a role in screening for GERD.